INVESTIGATION OF IN VITRO THROMBOLYTIC POTENTIAL AND PHYTOCHEMICAL NATURE OF CRINUM LATIFOLIUM L. LEAVES GROWING IN COASTAL REGION OF BANGLADESH
The study was carried out to investigate thrombolytic potential, and to find out possible phytochemical nature (group determinant of plant extract) of crude methanolic extract of leaves of Crinum latifolium L. Phytochemical analysis of the crude extract revealed the presence of alkaloid(s), carbohydrate(s), glycoside(s), phenol, tannin, protein(s), gum and mucilages. The thrombolytic nature of the plant was found significant (p < 0.001) when compared with the negative control (water) at different doses. The plant showed moderate clot lysis, i.e. 14.64±0.540%, 18.01±0.766%, 21.78±1.039%, 28.43±0.982%, and 33.84±1.749% at 2, 4, 6, 8, and 10 mg/ml concentrations respectively, while the standard (streptokinase) showed 47.27±1.998% clot lysis. Therefore, the study tends to suggest good thrombolytic activity of crude methanolic extract of C. latifolium leaves