119ASSOCIATION OF CLINICAL SYMPTOMS WITH SMOKING QUANTITY IN NORTHERN INDIAN COPD PATIENTS AT TERTIARY CARE HOSPITALCOPD is a complex mix of signs and symptoms in patients with chronic bronchitis and emphysema, diseases that largely result from cigarette smoking. Not all smokers acquire COPD. Surprisingly, there are no effective drug therapies for COPD that are able to significantly alter disease progression, and little is known of the underlying molecular mechanisms that are responsible for its occurrence. To evaluate the association of clinical symptoms with the smoking quantity in northern Indian population. We enroll 412 subjects’ 204 cases/208 controls) from the out patients department of pulmonary medicine Chhatrapati Shahuji Maharaj Medical University, (Erstwhile King George’s Medical College), UP, Lucknow. For the assessment of COPD we used GOLD guideline. A detailed medical history of risk factors viz., Smoking, tobacco chewing, biomass fuel exposure, occupation clinical and pulmonary function evolution were recorded, and for the analysis we use Chi square test to look the association between clinical symptoms with smoking quantity. No differences were observed between the clinical symptoms with the smoking quantity but most of the patients having 10-15 cigarette daily consumption. So we conclude that none of the clinical symptoms were associated with the smoking quantity.dr.kantskt@rediffmail.comResearch342012COPD,Chronic obstructive Pulmonary DiseaseShukla RK,Kant S,Bhattacharya S,Mittal BUniversity Chhatrapati Shahuji Maharaj Medical University (Erstwhile King George Medical College), Department of Pulmonary Medicine, 226003, Lucknow, India.,University Chhatrapati Shahuji Maharaj Medical University (Erstwhile King George Medical College), Department of Pulmonary Medicine, 226003, Lucknow, India.,University Chhatrapati Shahuji Maharaj Medical University (Erstwhile King George Medical College), Department of Physiology, 226003, Lucknow, India., Sanjay Gandhi Post Graduate Institute of Medical Sciences, Department of Medical Genetics, 226014, Lucknow, India.