137DESIGN, FORMULATION AND EVALUATION OF OFLOXACIN NANOPARTICLESThe aim of this study was to formulate and evaluate the ofloxacin nanoparticles to improve the therapeutic efficacy of ofloxacin by loading in nanoparticle drug delivery system. Nanoparticles are especially designed to release the drugs in the vicinity of the target tissue. Nanoparticles are solid colloidal particles with diameter ranging from 1-1000 nm. Ofloxacin nanoparticles was prepared by emulsion polymerization method by using Eudragit S-100 polymer as a continuous phase for four different ratios such as (Drug: Polymer) (1:1), (1:2), (1:3) and (1:4). The formulated nanoparticles was evaluated for external morphological studies using scanning electron microscope, Drug content, invitro release studies and IR spectral analysis. In IR study reveals that more in no major shifting as well as non less of functional groups peak between the drug, polymer and drug loaded nanoparticles. The invitro release study showed that the formulation ratio (1:1) gives the better sustained effect over 96.54 % of drug was released at 8 hours. This study conclude that the ofloxacin nanoparticles are suitable candidates to produce good antibiotic prolong action.subbupharm@gmail.comResearch352012Ofloxacin,Nanoparticles,Eudragit S-100,Emulsion Polymerization,In vitro evaluationL.Subramanian,V.Ganesan,N.Venkateshan, P.SolairajPeriyar Maniammai University, Thanjavur, Tamilnadu, India.,Erode College of Pharmacy, Erode, Tamilnadu, India.,Sankaralingam Bhuvaneshwari College of Pharmacy, Sivakasi, Tamilnadu, India.,Sankaralingam Bhuvaneshwari College of Pharmacy, Sivakasi, Tamilnadu, India.