138FORMULATION AND EVALUATION OF ORAL DISPERSIBLE TABLETS OF ATENOLOL BY USING SUPER DISINTEGRATESThe aim of this study is to formulate and evaluate an oral dispersible drug delivery system (ODDDS) containing an antihypertensive drug atenolol, by using different super disintegrates. Oral dispersible tablet form is designed to allow administration of an oral solid dosage form in the absence of water or fluid intake. Such tablets readily dissolve or disintegrate in the saliva generally within <60seconds. The main objective of the present study was undertaken for formulation and evaluation of oral dispersible tablets by direct compression technique. In the present project work, an attempt was made to formulate Atenolol as an oral dispersible tablet using different Superdisintegrants (like Crosspovidone, croscarmellose sodium, sodium starch glycolate etc) in different ratios by direct compression method. The formulations were evaluated for hardness, friability, weight variations, thickness, drug content and in vitro dissolution profile.karthikmpharma@gmail.comResearch352012Atenolol,Super disintegrates,Direct compression method,Crosspovidone,Anti-hypertensiveM. Karthikeyan,M. Karthikraja,C. Roosewelt,D. Lokesh,Y. Venkateswarlu,Y. NareshDepartment of Pharmaceutics, Jagan’s College of pharmacy, Nellore, Andhra Pradesh, India.,Department of Pharmaceutics, S. Chavaan’s College of pharmacy, Nellore, Andhra Pradesh, India,Department of Pharmaceutics, Jagan’s College of pharmacy, Nellore, Andhra Pradesh, India.,Department of Pharmaceutics, Jagan’s College of pharmacy, Nellore, Andhra Pradesh, India.,Department of Pharmaceutics, Jagan’s College of pharmacy, Nellore, Andhra Pradesh, India.,Department of Pharmaceutics, S. Chavaan’s College of pharmacy, Nellore, Andhra Pradesh, India