139DRUG RELEASE KINETICS FROM MATRIX COMBINING MIXTURE OF HYDROPHILIC AND HYDROPHOBIC POLYMERS ON MEBEVERINE HCL, ON SITE SPECIFIC DRUG RELEASE TO THE COLONThe investigation of the present work is the modification of the release behavior of matrix tablets of Mebeverine Hydrochloride to reduce the dosing frequency and to improve patient compliance. The matrix tablets were prepared by the combination of hydrophilic and hydrophobic polymers, using HPMC (E5V and 1 LAKH and Eudragit L100). The drug polymer interaction was investigated by FTIR and their results directed further course of formulation. The tablets were prepared by wet granulation technique. Prepared formulations were evaluated for various parameters like weight variation, hardness, friability, % drug content and swelling index. Tablets were subjected to in vitro drug release studies. The formulations F4 containing HPMC (E5V), Eudragit L100 showed good release retardation. The kinetics of the dissolution process was determined by analyzing the dissolution data using various kinetic equations, e.g. Zero-order, First-order, Higuchi and Korsmeyer equations. All the prepared formulations showed high regression value for Zero-order release kinetics. The combination of hydrophilic and hydrophobic polymers can effectively control the drug release for freely water-soluble drugs in case of controlled release formulations which are the upcoming dosage forms for patient compliance in all aspects. Kinetic treatment to the in vitro release data revealed that the drug release followed zero order non - fickian diffusion, It means the release of drug from tablet dissolution and diffusion both mechanisms are used.prathap.nil@gmail.comResearch352012 Mebeverine hydrochloride,Hydroxyl propyl methyl cellulose,Eudragit,Evaluation parameters,in vitro release,Kinetic treatmentM. Prathap,A.M.S. Sudhakar Babu,D. DhachinamoorthiDepartment of Pharmaceutics, A.M.Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.,Department of Pharmaceutics, A.M.Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.,Department of Pharmaceutics, QIS College of Pharmacy, Ongole, Andhra Pradesh, India.