157FORMULATION AND EVALUATION OF SELF NANOEMULSION DRUG DELIVERY SYSTEM OF LOW SOLUBILITY DRUG “SIMVASTATIN” FOR IMPROVED SOLUBILITY AND BIOAVAILABILITYThe aim of the present work was to prepare a novel self nanoemulsion drug delivery system (NE) to enhance the solubility, dissolution rate and ultimately the oral bioavailability of a poorly water soluble drug, Simvastatin. The prepared self nanoemulsion of simvastatin was charactriesed by using techniques like FTIR analysis for investigating the drug-excipients interactions, zeta potential, viscosity determination, drug entrapment efficiency and thermodynamic stability studies. The invitro drug release profile of self-nanoemulsion was carried in phosphate buffer Ph 7.4 for 1 hr by using USP dissolution apparatus type-II device. From the invitro dissolution data, F5 formulation was found that the drug release is best and the cumulative % of drug release was 98.62% respectively. The promising formulation F5 was found by evaluation studies were compared with Marketed product (Simvas 10mg), the F5 formulation gave 98.62% of the drug release and the Marketed product gave 45.19 % of drug release in 1 hr of dissolution study. The in-vitro intestinal permeability results exhibits the drug diffused at a faster rate from the self nanoemulsion system than from the tablet dosage form. After 1 hour of diffusion, 76.54% of drug was diffused from the self nanoemulsion system, as compared with 34.23% diffused from the tablets. Therefore the developed ME formulation improved the Solubility and in-vitro drug release of Simvastatin when compared with commercial tablet formulation. ananthmadhu@gmail.comResearch362012Simvastatin,Self Nanoemulsion,Characterization,In vitro release studies,Stability studiesA.Madhu Babu,B.Prakash Rao,P.Sudhakar,K.R.S.Sambasiva Rao Department of Pharmaceutics, Deevena College of Pharmacy, Suryapeta, A.P, India.,Department of Pharmaceutics, Karnataka College of pharmacy, Bangalore, Karnataka, India.,Department of Biotechnology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.,Department of Biotechnology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.