150MULTI-COMPONENT MODE ANALYSIS OF OLMESARTAN MEDOXOMIL AND AMLODIPINE BESYLATE IN COMBINATION AS TABLET DOSAGE FORM BY UV SPECTROSCOPYA simple, accurate, reproducible and resourceful method for the simultaneous determination of olmesartan medoxomil and amlodipine besylate was developed by UV-visible double beam spectrophotometer (Shimadzu UV- 1601) using multicomponent mode analysis with matched pair quartz cells corresponding to 1 cm path length. The proposed method used economical solvents and instrument. Olmesartan medoxomil and amlodipine besylate in combination were used as tablet dosage forms in the ratio of 4:1. Linearity was established for olmesartan medoxomil and amlodipine besylate in the range of 2- 20 µg/mL.The reproducibility of sample was expressed in terms of S.D. and % R.S.D. The percentage recoveries of olmesartan medoxomil and amlodipine besylate were found in the range of 99-101 %. Aqueous methanol was used as a blank. The validation studies were performed according to International Conference on Harmonization (ICH) guideline. The results of specificity studies reveal that both the drugs degraded in presence of acid. Ruggedness was performed under three different conditions such as different days, different analysts and intraday. The results show the % RSD values < 2.0 % signifies the precision of the method.dineshkawade@yahoo.co.inResearch352012Olmesartan medoxomil,Amlodipine besylate,UV-Spectroscopy,Multi-component mode analysis [MMA]Dinesh P. Kawade,Sapan K. Shah,Alpana J. AsnaniDepartment of Pharmaceutical Chemistry, J. L. Chaturvedi College of Pharmacy, Electronic zone building, MIDC, Hingna road, Nagpur-440 016, Maharashtra, India.,Department of Pharmaceutical Chemistry, J. L. Chaturvedi College of Pharmacy, Electronic zone building, MIDC, Hingna road, Nagpur-440 016, Maharashtra, India.,Department of Pharmaceutical Chemistry, J. L. Chaturvedi College of Pharmacy, Electronic zone building, MIDC, Hingna road, Nagpur-440 016, Maharashtra, India.