160ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF RAMIPRIL AND TELMISARTAN IN PHARMACEUTICAL DOSAGE FORM BY USING RP-HPLC METHODA simple and reliable reverse phase high-performance liquid chromatography method was developed and validated for analysis of Ramipril and Telmisartan in pure and pharmaceutical dosage form. The method was developed on symmetric C18 (4.6 x 150mm, 5m, Make: Zorbax), with a mobile phase of phosphate buffer (PH 3.0): Acetonitrile (55:45) %v/v. The effluent was monitored by Waters HPLC model containing Alliance 2695 with 2487 detector, variable wavelength prominence UV/ VIS detector SPD-20A (VP series). Calibration curve was linear over the concentration range of 1.25-6.25μg/ml for Ramipril and 10-50μg/ml for Telmisartan. Recovery of Ramipril and Telmisartan was found to be in the range of 99.1 -100.2%.The limit of detection (LOD) and quantification (LOQ) were 2.97 and 9.84 for Ramipril and 3.0 and 9.95 for Telmisartan, respectively. The retention time and run time was very short; hence it is cost effective, making it more economical and rapid. Hence, this method can be used for the analysis of large number of samples.nnraopharma@gmail.comResearch362012Ramipril,Telmisartan,RP-HPLC,ValidationNarasimha Rao Nalluri, Rajavel P,Venketeswara Rao P,Sudhakar Babu AMSDepartment of Pharmaceutical Analysis, A.M. Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India,Department of Pharmaceutical Analysis, A.M. Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India,Department of Pharmaceutical Chemistry, A.M. Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India., Department of Pharmaceutics, A.M. Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India