161METHOD DEVELOPMENT AND VALIDATION FOR THE ASSAY OF VILAZODONE IN BULK AND FORMULATION BY USING RP-HPLC TECHNIQUEA simple, precise, rapid and accurate RP-HPLC method was developed and validated for assay of Vilazodone in tablet dosage form. Isocratic elution at a flow rate of 1mL/min was employed on a symmetry Chromosil C18 (250x4.6mm, 5µm in particle size) at ambient temperature. The mobile phase consisted of methanol: water 25: 75 v/v, (PH 4.0 with 0.1% Ortho phosphoric Acid). The UV detection wavelength was 224nm and 20µl sample was injected. The retention time for vilazodone was 4.05 min. The percentage RSD for precision and accuracy of the method was found to be less than 2%. The method was validated as per the ICH guidelines. The method was successfully applied for qualitative analysis of vilazodone in tablet dosage form and bulk drug.indian_spidy_99@yahoo.comResearch362012Vilazodone,RP-HPLC,UV detection,Recovery,Precise and 224nmB. Parameswara Reddy,N. Pramod,P. Venkateswararao,A.M.S. Sudhakar babuDepartment of Pharmaceutical Analysis, A.M Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.,Department of Pharmaceutical Chemistry, A.M Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.,Department of Pharmaceutical Chemistry, A.M Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India., Department of Pharmaceutics, A.M Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India