171ANTICONVULSANT ACTIVITY OF LEAF EXTRACT OF VIGNA RADIATA (L.) WILEZEKVigna radiata. (Fabaceae) a widely growing plant has been reported to possess number of medicinal properties. The purpose of the present study was to evaluate scientifically the anticonvulsant activity of Chloroform and Methanol extract of leaves of the plant Vigna radiata in albino Wistar rats on electrically and chemically induced seizures. The anti‐convulsant activity of different extracts of Vigna radiata leaves was studied against seizures induced by maximal electroshock seizures (MES). In the MES test, the methanol extract (100 & 200mg/kg, i. p) Vigna radiata of leaves showed the most significant (p<0.01) anticonvulsant effect by decreasing the duration of Hind Limb Tonic Extension (HLTE), clones and also the duration of stupor phase than other extracts when compared to control group. The ED50 dose of Phenytoin (25 mg/kg, i.p) was used as standard. In conclusion it was realized that methanol extract (ED50 = 100 & 200 mg/kg, i.p) is more potent than other extracts in showing anti-seizure effects. pharma.nisha@gmail.comResearch372012Vigna radiata,Methanol extract,Chloroform extract,Maximal electroshock-induced convulsionsM. Nishanthi,M. Vijey Aanandhi,M. Shankar,N.L. Gowri Shankar,V.D.T. Basavaraj,B.Vijayakumar Sri Venkateswara College of Pharmacy, R.V.S Nagar, Chittoor – 517127, Andhra Pradesh, India.,School of Pharmaceutical Sciences, Vels University, Pallavarm, Chennai-600117, Tamilnadu, India.,Swami Vivekananda Institute of Pharmaceutical Sciences, Vangapally - 508286, Andhra Pradesh, India.,Swami Vivekananda Institute of Pharmaceutical Sciences, Vangapally - 508286, Andhra Pradesh, India., Sri Venkateswara College of Pharmacy, R.V.S Nagar, Chittoor – 517127, Andhra Pradesh, India., Sri Venkateswara College of Pharmacy, R.V.S Nagar, Chittoor – 517127, Andhra Pradesh, India.