17EVALUATE THE ANTI-DIABETIC ACTIVITY OF FICUS MICROCARPA L. IN ALLOXAN INDUCED DIABETES IN ALBINO WISTAR RATSFicus microcarpa L. commonly known as Chinese banyan belongs to the Division-Magnoliophyta, Order-Urticales, and Family- Moraceae, is used in folk medicine because of its treatment in diabetes, ulcers, burnig sensations, haemorrages, leprosy, itching, liver disease and tooth ache. Aim of this study to investigate the anti-diabetic activity of petroleum ether extract of Wrightia tinctoria L. (PWT) in alloxan induced diabetes in albino wistar rats. Alloxan was administered as a single dose (120mg/kg, b.wt) to induce diabetes. Administration of pet ether extracts from leaves of Ficus microcarpa L. (200 &400mg/kg body weight/day) for 14 days, to alloxan-induced diabetic rats. The fasting blood sugar levels and serum biochemical analysis in alloxan-induced diabetic rats were investigated. Oral administration of PFM (200 & 400 mg/kg) for 14 days exhibited a significant reduction in serum glucose, total cholesterol, LDL, VLDL and triglycerides in alloxan diabetic rats. The anti-diabetic activities of the pet ether extract of Ficus microcarpa L. (PFM) were similar to those produced by glibenclamide at 2.5mg/kg (positive control, p < 0.05). The results of this work suggest that Ficus microcarpa L. may have new clinical significant choice in diabetes mellitus illness, and could explain the basis for its traditional use to manage diabetes-related complications by rural community of southern of India.mohana_cog@yahoo.co.inResearch122010Ficus microcarpa L,Antidiabetic Activity, Alloxan Induced Diabetes,Total Cholesterol,HDL,LDL,VLDL,TriglyceridesS. Mohana Lakshmi,A. Saravana Kumar,M.Y. Aneef,K. Upendra reddy,P. Pradeep kumar,M. Divya,S. NiroshaSree Vidyanikethan College of Pharmacy, Sree Sainath Nagar,Tirupati – 517 502, A.P.,Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar,Tirupati – 517 502, A.P.,Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar,Tirupati – 517 502, A.P.,Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar,Tirupati – 517 502, A.P.,Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar,Tirupati – 517 502, A.P.,Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar,Tirupati – 517 502, A.P.,Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar,Tirupati – 517 502, A.P.