197FORMULATION, IN VITRO KINETIC AND STABILITY STUDIES OF METFORMIN HCL EXTENDED RELEASE TABLETSThe investigation was concerned with design and characterization of oral extend release tablets of Metformin hydrochloride, in order to improve efficacy and better patient compliance; there is a need to develop a formulation for this drug which overcomes problems such as Minimize accumulation for chronic use, to reduce fluctuation in drug release, minimize the cost and the formulation as compared to conventional tablet. The study involved pre-formulation of drug and granules, formulation and processing development along with evaluation of the tablets and Comparative evaluation with marketed sample. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content. Optimized formulations were evaluated for in vitro dissolution test. The optimized formulation of F-9 Pharmacokinetic parameters is evaluated. The result of stability studies conducted on F-9 at 25˚C and 60% RH, there is no change in physical appearance, hardness, thickness, drug content and In vitro dissolution profile, hence these formulations were found to stable at tested temperature. From these result F-9 has achieved the prolonged drug release, patient compliance, and cost effectiveness.yarlagaddaac@yahoo.co.inResearch412013Metformin hydrochloride,Metformin hydrochloride,Wet granulation technique,In vitro dissolution test ,Stability studiesY. Ankamma Chowdary,Venkata Suresh JilakaraDepartment of Pharmaceutics, NRI College of Pharmacy, Pothavarappadu, Agiripalli, Krishna district, Andhra Pradesh, India.,Department of Pharmacognosy and Phyto Pharmaceutical, KLR Pharmacy College, Contractor‟s Colony, Paloncha, Khammam, Andhra Pradesh, India