19FORMULATION AND EVALUATION OF GASTRIC ORAL FLOATING TABLET OF GLIPIZIDEThe objective of this study was to formulate and evaluate a Gastric oral floating tablets of Glipizide and invitro release evaluation. Ten formulation containing hydrophilic polymers, that are hydroxy propyl methyl cellulose K15 and eudragit RS100, gas generating agent, sodium bi carbonate and other release promoters such as sodium lauryl sulphate and polyvinyl pyrolidone were used. The tablet were compressed and evaluated with different parameters like angle of repose, Carr’s index diameter thickness, average weight, hardness, friability, drug content, invitro buoyancy study and kinetic drug release data. The tablets remained buoyant over 8 hours in the release medium. The amount of sodium bi carbonate found to be significant for not only to remaining buoyant without causing disintegration of the tablet, but also to release of drug in acidic medium and solubilizing agent amount found to be significant as for as the release of the drug is concern from the ten formulation. F9 is a best formulation to determine the mode of release, the data was subjected to higuchi’s and peppas model. senthil_ac12@yahoo.inResearch122010Floating drug delivery system, controlled drug release,Glipizide,Hydroxy propyl methyl cellulose K15A. Senthil,P. Suresh Kumar, CH. Narasimha Raju,S. MohideenDept of Pharmaceutics, Browns College of Pharmacy, Khammam, AP,Dept of Pharmaceutics, Browns College of Pharmacy, Khammam, AP,Dept of Pharmaceutics, Browns College of Pharmacy, Khammam, AP,Dept of Pharmaceutics, Browns College of Pharmacy, Khammam, AP