219SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SUBSTITUTED PYRIMIDINE DERIVATIVES FROM 2-ACETYL-5- METHYLFURAN DERIVED CHALCONESA number of 2,4,6-trisubstituted pyrimidines were reported to possess diverse biological activities like antimicrobial, antidepressant, analgesic, anti-inflammatory, anticancer, antiviral, anti leishmanial, anti-tubercular, anti-HIV and anti-malarial activities. However, pyrimidines with antimicrobial and anticancer activities are being reported increasingly and hence it was felt worthwhile to evaluate them for these activities. The finding that 2,4-diaminopyrimidines inhibit the growth of microorganisms by interfering with their utilization of folic acid led to an intensive search for anti-infective agents in this class of heterocyclic compounds. Synthesis and purification of 2,4,6-trisubstituted pyrimidines from the chalcones obtained from 2- acetyl-5-methylfuran and screen the synthesized pyrimidines for their antimicrobial activity will be finding way to synthesis of similar compounds for various biological activities in future prospectivereddy.rambabu1155@gmail.comResearch4320132-acetyl-5-methylfuran,Chalcones,Substituted pyrimidinesReddy Rambabu,Y. Rajendra Prasad,S. VidyadharaDepartment of Pharmaceutical Chemistry, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India.,Department of Pharmaceutical Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India.,Department of Pharmaceutical Chemistry, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India.