226ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF TELMISARTAN AND HYDROCHLOROTHIAZIDE IN DISSOLUTION BY RP-HPLCA new and simple RP-HPLC method has been developed and validated for the analysis of Telmisartan and Hydrochlorothiazide in tablet formulation. The process of dissolution has been carried out with apparatus USP Type II, RPM- 75 and Time point - 60min. pH 7.5 phosphate buffer is the dissolution media as well as diluent. Telmisartan and Hydrochlorothiazide is analyzed using HPLC whose optimized chromatographic conditions include: column- C8 (250mm x 4.6 x 5µ particle size), column oven temperature of 40°C over a run time of 7mins, injection temp 25°C with volume of 50µL at a flow rate of 1.5mL/min. Ammonium phosphate buffer and Acetonitrile (60:40) is used as mobile phase. Validation parameters selectivity, precision, linearity, accuracy, Robustness all are within the limit so method was validated it is use full to pharmaceutical analysis dhanadlx@gmail.comResearch432013Telmisartan,Hydrochlorothiazide,Dissolution,RP-HPLCDhanalakshmi K,Tatineni Vasuki,Nagarjuna reddy,Jotheiswari DKLR Pharmacy College, Palvoncha, Khammam, Andhra Pradesh, India.,KLR Pharmacy College, Palvoncha, Khammam, Andhra Pradesh, India.,KLR Pharmacy College, Palvoncha, Khammam, Andhra Pradesh, India.,Sri Venkateswara College of Pharmacy, R.V.S. Nagar, Chittoor, Andhra Pradesh, India