259COMMIPHORA WIGHTII DOWN REGULATES HMG COA REDUCTASE IN HYPERLIPIDEMIC RATSHyperlipidemia is a consequent event of lipoprotein metabolism failure. It results an excessive accumulation of lipids in blood. It may lead to hypercholesterolemia, hypertriglyceridemia or both. Dyslipidemia or hyperlipidemia gives rise to various grave diseases like obesity, hypertension, atherosclerosis and strokes. Herbal remedies plays vital role in the regression of hyperlipidemic disorders with least side effects. One of the most extensively explored and examined herbal drug extracted from the plant Guggul-Commiphora wightii (Arn.) Bhandari is reputed for its hypolipidemic action. In the present study, the effect of ethyl acetate extract of C. wightii resins (EACWR) on the down regulation of HMG Co.A reductase activity have been investigated in hyperlipidemic rats elicited by high fat diet for 60 days. The study design included six groups of rats (n=6): Control and hyperlipidemic rats while other four groups of hyperlipidemic rats treated with ethyl acetate extract of C. wightii (200, 400 and 800 mg/kg bw) and statins 1.5 mg/kg bw. Results of the present study confirmed the most effective significant reduction (p<0.05) occurs at EACWR (400 mg/kg bw) in HMG-CoA reductase activity, oxidative stress and body weight near to control. It also improves liver functions in hyperlipidemic animal models. This investigation is also warranting its hypolipidemic activity.sandeeptripathiphd@gmail.comResearch462013 Commiphora wightii,Hyperlipidemia, HMG-CoA reductaseMadhvi Bhardwaj,Anupam Kumar,Sandeep Tripathi,Sandeep KumarDepartment of Advance Sciences & Biotechnology, Nims Institute of Engineering & Technology, NIMS University, Shobha Nagar, Jaipur, Rajasthan, India,Department of Biotechnology, Lovely Professional University, Jalandhar, Punjab, India.,Department of Advance Sciences & Biotechnology, Nims Institute of Engineering & Technology, NIMS University, Shobha Nagar, Jaipur, Rajasthan, India,Department of Advance Sciences & Biotechnology, Nims Institute of Engineering & Technology, NIMS University, Shobha Nagar, Jaipur, Rajasthan, India