25EFFECT OF 2-DEOXY- D- GLUCOSE AND CYCLOPHOSPHAMIDE MEDIATED MODIFICATION OF INDUCED GENETIC DAMAGE IN ALBINO MICEThe micronucleus test (MNT) on mammalian bone marrow is widely accepted as a toxicological screening test used as a sensitive method for measuring genetic damage. The aim of the current study was to evaluate frequency of micronucleated polychromatic erythrocytes (MNPCEs) in the bone marrow of mice treated with 2-Deoxy -D- Glucose (2DG) and cyclophosphamide (CPH). Seven groups (n=10) of animals were selected and test compounds was injected intraperitoneally. The mean MnPCE values are found a significant inhibition in micronuclei formation was noticed with Cyclophosphamide 125 mg/kg body weight dose (p < 0.001) to compare with 2 DG and control groups. When we use 2-DG in the MN analysis, it was observed that the 0.5 mg/kg MnPCE level was higher in treated mice as compared to controls. The 1.0 mg/kg MnPCE level was lower. The 2.0 mg/kg MnPCE level also was lower however; the differences were highly significant (p < 0.001). The combination of Cyclophosphamide and 2-Deoxy -D- Glucose 0.5 mg/kg MnPCE level were significantly increased and 1 mg/kg body weight was significantly decreased, overall the combination results were showing (p < 0.001). This study revealed that mice MN assay can be used as a genotoxicological test-system since some methodological particularities were observedrkgenes@gmail.comResearch212011Micronucleus assay,DNA damage,Cyclophosphamide,2-Deoxy -D- GlucoseV. Ramakrishnan,S. Gowtham kumar,N. Madhusudhanan2,G. Thiyagarajan,and S. GovindarajuDepartment of Medical bionanotechnology, Chettinad University, Kelambakkam, Chennai 603103, India.,Department of Medical bionanotechnology, Chettinad University, Kelambakkam, Chennai 603103, India.,Department of Pharmacology, Chettinad University, Kelambakkam, Chennai-603103, India.,Department of Biotechnology, Central Leather Research Institute, Adyar, Chennai 600020, India., Department of Bio-Statistics, Chettinad University, Kelambakkam, Chennai-603103, India.