274PREPARATION AND CHARACTERIZATION OF ORO DISPERSIBLE TABLETS OF GLIMEPRIDE- PVP K30 SOLID DISPERSIONGlimepride is a sulfonyl urea compound used to treat type II diabetes Mellitus and belongs to Class II of Biopharmaceutical classification system. Here, Solid dispersion technique is used to enhance the solubility. Solid dispersion of Glimepride is prepared by dissolving drug and polyvinyl pyrrolidine K30 in Dichloromethane and the solvent is removed by rotary evaporator under reduced pressure. The solubility increased around twenty times greater when drug and carrier is used in1:10 ratios. The Oro dispersible tablets were prepared by using Sodium starch glycollate, cross caramellose sodium, pregelatinized starch and polacrilin potassium as super disintegrants. The rapid disintegration (24 sec) is obtained to polacrilin pottassium (10%) and maximum drug release (85.6%) obtained in 10 min. From these results it is concluded that solubility of glimepride is increased by preparing solid dispersion and rapid bioavailability is observed by preparing orodispersible tablets.karthikeya7723@gmail.comResearch482013Glimepride, Solid dispersion,PVP- K30,SuperdisintegrantsKishore K,Sudhakara Reddy P,Srininvas Reddy D,Maneshwar T,Kiran Kumar V,Raju LVaageswari College of Pharmacy, Karimnagar, AP, India-505481.,Vaageswari College of Pharmacy, Karimnagar, AP, India-505481.,Vaageswari College of Pharmacy, Karimnagar, AP, India-505481.,Unity College of Pharmacy, Raigir, Bhongir, Nalgonda, AP, India-508116.,Unity College of Pharmacy, Raigir, Bhongir, Nalgonda, AP, India-508116.,Unity College of Pharmacy, Raigir, Bhongir, Nalgonda, AP, India-508116.