270AMELIORATIVE EFFECTS OF AQUEOUS WATER LEAF EXTRACT (TALINUM TRIANGULARE) AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN ADULT WISTAR RATSReports have shown many cases of the effects of cytotoxic drugs on body tissues such as the liver and pancreas in response to increasing needs for administration of cytotoxic drugs which invariably result in increased incidence of some diseases. This study was designed to assess ameliorative effects of aqueous extract of water leaf on carbon tetrachloride induced hepatotoxicity in adult wistar rats. Twenty-five wistar rats were divided into five groups of five (5) rats each weighing between 200g-250g. Group A served as control, group B rats were given 0.5ml/kg of carbon tetrachloride, group C (withdrawal) was given 0.5ml/kg of carbon tetrachloride and withdrawn for a week, group D and E was 500mg/kg and 1000mg/kg of aqueous extract of Talinum triangulare respectively and 0.5ml/kg of carbon tetrachloride intraperitoneally once daily for seven days. The findings revealed the adverse effects of carbon tetrachloride, the recovery effect of the withdrawal and it also showed a dose dependent suppression of oxidative damage in the liver following the administration of aqueous extract of Talinum triangulare at high dose (p<0.05). The serum hepatic marker enzymes significantly reduced in the treated rats which corroborated the improvement in hepatic histology of the distorted hepatic tissue following carbon tetrachloride exposure. This study indicated the hepatoprotective effects of Talinum triangulare against carbon tetrachloride induced hepatic damage in wistar ratsaadeshinaajibade@yahoo.co.ukResearch472013Hepatotoxicity,Oxidative damage,CCl4,Hepatoprotective,Talinum triangulare,Wistar ratsAjibade AJ,Fakunle PB,Olayemi OT,Ehigie Leo,Abosede OYDepartment of Anatomy, Ladoke Akintola University of Technology Ogbomoso, Oyo State, Nigeria.,Department of Anatomy, Ladoke Akintola University of Technology Ogbomoso, Oyo State, Nigeria.,Department of Anatomy, Ladoke Akintola University of Technology Ogbomoso, Oyo State, Nigeria., Department of Biochemistry, Ladoke Akintola University of Technology Ogbomoso, Oyo State, Nigeria,Department of Anatomy, Ladoke Akintola University of Technology Ogbomoso, Oyo State, Nigeria.