294FORMULATION AND EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM OF MESALAMINEThe present investigation was aimed to develop pH dependent system as colon drug delivery system of Mesalamine by using Cellulose acetate phthalate (CAP), Eudragit S-100 and Eudragit L-100 as a coating material by compression coating technique. The colon drug delivery system is designed such that the innermost part consists of a core tablet of Mesalamine with polymers HPMC of different grades which is then compression coated with pH dependent polymers CAP, Eudragit S-100 and L-100 that offers a greater degree of protection from premature drug release in upper GI tract. The prepared core and coated tablets were evaluated for both pre compression and post compression parameters and they were complied with I.P limits. The in vitro drug release studies were conducted in simulated gastric fluid (pH 1.2), simulated intestinal (pH 7.4) and simulated intestinal fluid (pH 6.8) to simulate gastro intestinal tract. From the above results, the Eudragit S-100 formulation was considered better among other formulations. From FTIR studies, it was concluded that there was no possibility for drug excipient interaction.sandhyapasikanti@gmail.comResearch492013 Colon specific drug delivery, Eudragit S-100, FTIR studies, Inflammatory Bowel DiseaseP. Sandhya,Hina Arshiya,Divya Bhatnagar,P.PoornimaShadan Womens College of Pharmacy, Khairatabad, Hyderabad, Andhra Pradesh, India.,Shadan Womens College of Pharmacy, Khairatabad, Hyderabad, Andhra Pradesh, India.,Shadan Womens College of Pharmacy, Khairatabad, Hyderabad, Andhra Pradesh, India.,Shadan Womens College of Pharmacy, Khairatabad, Hyderabad, Andhra Pradesh, India.