302ALPRAZOLAM INDUCED BIOCHEMICAL CHANGES IN HUMAN ERYTHROCYTE MEMBRANE AND PLASMAAnxiolytics are the drugs for short term relief of severe and disabling anxiety. Alprazolam is a benzodiazepine whose hydroxylated derivative shows medium anxiolytic and antidepressant action. It acts by binding to a specific regulatory site on GABAA receptor thus enhancing the inhibitory effect of GABA and also alprazolam induces some important biochemical changes in human erythrocyte membrane and plasma. Many tests have shown that response is an increase in behavioural activity, so it is clear that alprazolam produces something more than nonspecific sedation. Possible new approaches based on neuro peptide mediators are being investigated. rajeev.vasavi@gmail.comResearch4102013Anxiolytics,Benzodiazepines,GABA,Sedation,Alprazolam (APZ)Vasavi Padma Kodamasimham,N.CH. Varadacharyulu,M. Rajeev kumar,D. Sailaja,Shaik Irfan Pasha, Sheik MuddasarDepartment of Bio-Chemistry, MAX Institute of Pharmaceutical Sciences, Velugumatla, Khammam Urban, Khammam – 507318, Andhra Pradesh, India.,Department of Bio-Chemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India,Department of Pharmaceutics, MAX Institute of Pharmaceutical Sciences, Velugumatla, Khammam Urban, Khammam – 507318, Andhra Pradesh, India.,Department of Pharmaceutics, MAX Institute of Pharmaceutical Sciences, Velugumatla, Khammam Urban, Khammam – 507318, Andhra Pradesh, India.,Department of Pharmaceutics, MAX Institute of Pharmaceutical Sciences, Velugumatla, Khammam Urban, Khammam – 507318, Andhra Pradesh, India.,Department of Pharmaceutics, MAX Institute of Pharmaceutical Sciences, Velugumatla, Khammam Urban, Khammam – 507318, Andhra Pradesh, India.