327ANTIHYPERGLYCEMIC, HYPOLIPIDEMIC AND ANTIOXIDENT EFFECT OF AQUEOUS EXTRACT OF CORIANDER SATIVUM (SEED) AND GINGER OFFICINALE (RHIZOME) COMBINATION IN STREPTOZOTOCIN INDUCED DIABETES MELLITUS RATSHypoglycemic drugs are either too expensive or have undesirable side effects including hematological, coma and disturbances of liver, kidney. Limiting of diabetes without any side effects is still a challenge to the medical system. This leads to exert effort to search for effective, safer and less cost of antidiabetic natural drugs. The present study involves combination effect of Coriander sativum (seeds) and Ginger officinale (rhizome) in streptozotocin induced diabetes rats and their synergistic effect with glibenclamide. Aqueous extract of ginger (rhizome) and coriander (seeds) shows significant (p<0.05) reduction in blood glucose level and shows synergistic effect with glibenclamide in streptozotocin induced wistar rats. And these combination therapies showed an improved anti hyperglycemic activity and significant reduction in total cholesterol, LDLcholesterol, VLDL-cholesterol and triglycerides. And the activities of the enzymes SOD, CAT, GSH and GPX were increased and it can provide safe and effective option for the drug combination that may be very useful for the effective improvement of hyperglycemia kumaraswamy.barla@gmail.comResearch4122013Coriander,Ginger,Hypoglycemia,Lipid profile,Glibenclamide,Synergistic effect.Vijaya Durga P,Kumaraswamy Barla,Dhanaraju M,Ramachandran SGIET School of Pharmacy, Chaitanya Knowledge City, Rajahmundry, Andhra Pradesh – 533 296, India.,GIET School of Pharmacy, Chaitanya Knowledge City, Rajahmundry, Andhra Pradesh – 533 296, India.,GIET School of Pharmacy, Chaitanya Knowledge City, Rajahmundry, Andhra Pradesh – 533 296, India.,GIET School of Pharmacy, Chaitanya Knowledge City, Rajahmundry, Andhra Pradesh – 533 296, India.