350METHOD DEVELOPMENT AND VALIDATION OF GALANTAMINE HBr IN PHARMACEUTICAL CAPSULES DOSAGE FORM BY RPHPLCThe reverse phase high performance liquid chromatographic RP-HPLC method has been developed to quantify galantamine HBr in raw material and capsule formulations using C18 analytical reverse phase column. Mobile phase consisted of solution A and solution B (75:25v/v) pumped at a flow rate of 1ml/min at 250c column temperature. Run time was about 8min with symmetrical peaks. Galantamine HBr was detected by PDA detector at 230 nm with no interference of excipients. The method was linear over a concentration range of( 6-28gµ/ml) (R2-1.000). The LOD and LOQ of galantamine HBr were 0.1 and 0.6µg/ml respectively. The result obtained shows a good agreement with declared contents in pharmaceutical formulations. The proposed method is rapid accurate, economical and selective and it may be used for quantification analysis of galantamine in galantamine HBr capsules because of its sensitivity and reproducibilitybn.lavanya005@gmail.comResearch4122013RP-HPLC, Galantamine capsules,Galantamine api,Disodium orthophosphateNaga Lavanya B,Venkateswara Rao P,Sravani VD, Jasinth DDepartment of Pharmaceutical Analysis, A.M. Reddy Memorial College of Pharmacy, ANU University- Guntur, Andhra Pradesh, India.,Department of Pharmaceutical Analysis, A.M. Reddy Memorial College of Pharmacy, ANU University- Guntur, Andhra Pradesh, India.,Department of Pharmaceutical Analysis, A.M. Reddy Memorial College of Pharmacy, ANU University- Guntur, Andhra Pradesh, India.,Department of Pharmaceutical Analysis, A.M. Reddy Memorial College of Pharmacy, ANU University- Guntur, Andhra Pradesh, India.