353ANTI–DIABETIC ACTIVITY OF THE ISOLATED COMPOUNDS OF CORDIA SEBESTENA IN HIGH FAT DIET FED–STREPTOZOTOCIN– INDUCED DIABETIC RATSThe present study was designed to investigate the hypoglycemic and hypolipidemic activities of the isolated compound of an ethanolic leaf extract of Cordia sebestena (CS) in a high-fat diet (HFD) – streptozotocin (STZ) –induced diabetic rats. Male Wistar albino rats (180- 200 g) were fed with a high-fat diet for 2 weeks prior to intraperitoneal injection with streptozotocin (STZ, 50 mg/kg). To investigate the effect of long term administration of the hypoglycemic compound, diabetic animals were treated with vehicle (distilled water), CS (100 mg/kg) twice a day for 14 days. The long term administration of CS at a dose of 100 mg/kg significantly lowered the blood glucose and lipid profile concentrations when compared with the vehicle. The hepatic glycogen content was significantly higher in CS treated rats when compared to diabetic control. Moreover, CS significantly decreased the insulin resistance activity and glucose-6-phosphatase activity. In conclusion, the results indicate that CS is more potent in the amelioration of hyperglycemia and hyperlipidemia in HFD fed–STZ diabetic rats. Hence, CS is a potential source for oral anti–diabetic therapybahoursarath@gmail.comResearch4122013Cordia sebestena,Anti–Diabetic Activity,StreptozotocinSarathchandiran I,Gnanavel MGokula Krishna College of Pharmacy, Sullurupet– 524 121, Nellore District, Andhra Pradesh, India,Research Scholar, PRIST University, Vallam, Thanjavur – 613 403, Tamil Nadu, India