369ANTIHYPERGLYCEMIC ACTIVITY OF POLYHERBAL FORMULATION BSL-150 IN STZ-NICOTINAMIDE INDUCED DIABETES IN MICEDiabetes mellitus is a group of syndrome characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and proteins and an increased risk of complications from vascular diseases. A number of investigations on hypoglycemic agents from plants used in traditional medicine have been conducted and many of them were found with good activity. A polyherbal formulation BSL-150 is a formulation manufactured by Indu Pharma and consists of combination of herbs and various bhasmas. Each tablet of BSL-150 weighing 500 mg contains Gymnema sylvestere, Tinospora cardiofolia, Embellica officinalis and various bhasmas. In this study the formulation is screened for its antihyperglycemic activity in StreptozotocinNicotinamide induced diabetes in Swiss albino mice. The effect of single and repeated oral administration of BSL-150 on glycemic parameters, lipid profile and histology of pancreas in doses of 250, 500 and 1000 mg/kg is evaluated. The significant (p<0.001) reduction in the glycemic parameters, and lipid profile (p<0.05) in BSL-150 treated groups was observed as compared to diabetic control group. While no significant (p<0.001) change in Serum and Pancreatic insulin level was observed in the animals treated with BSL-150 on the other hand there was significant increase (p<0.001) in Liver glycogen content in animals treated with BSL-150 as compared to the diabetic control group. The histological studies of pancreas also showed the decreased tissue damage in the BSL treated groups as compared to diabetic control group. The results indicate that BSL 150 possesses potential antihyperglycemic activity in STZ- Nicotinamide induced diabetes in micevaishaliundale@gmail.comResearch4122013Diabetes mellitus,BSL-150, STZ- Nicotinamide,AntidiabeticVaishali R. Undale,Ashok V. Bhosale,Chandrashekhar D. UpasaniDepartment of Pharmacology, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad. Tal: Purandar, Dist: Pune, India, Pune District Education Association’s, Seth Govind Raghunath Sable, College of Pharmacy, Saswad. Tal: Purandar, Dist: Pune, India,Department of Pharmacology, SJNB’s Shri Sureshdada Jain College of Pharmacy, Neminagar, Chandwad, Nashik, India