376FORMULATION, OPTIMIZATION AND EVALUATION OF LORATADINE GASTRO RETENTIVE TABLETSLoratadine is a long-acting tricyclic antihistamine with selective peripheral histamine H1-receptor antagonistic activity. In this study Loratadine gastro retentive floating tablets were prepared and optimized the release of Loratadine by using HPMC K4 M and HPMC K15 M as polymers. The tablets prepared by direct compression technique and evaluated by physical parameters and in vitro dissolution parameters. A total nine formulations were prepared with varying polymer concentrations. All tablets were acceptable with strength was observed in tablets formulated with HPMC K4 M and HPMC K15 M. Formulation F9 showed maximum release 98% in 10 hrs. FT-IR studies showed no evidence of interaction between drug and polymersanishbujji@gmail.comResearch4122013Loratadine,Gastro retentive Floating tablets,HPMC,In vitro dissolution and direct compressionAnish Kumar D,Jhansi Rani M, Sudhakar Babu AMS,Venkateswara Rao P Department of Pharmaceutics A. M. Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India., Department of Pharmaceutics A. M. Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India., Department of Pharmaceutics A. M. Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.,Department of Pharmaceutical Chemistry, A. M. Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India