381SYNTHESIS AND CHARACTERIZATION OF SILVER NANOPARTICLES FROM ANDROGRAPHIS PANICULATA (LINN.) AND IT’S CYTOTOXICITY AGAINST SHEEP’S BONE MARROW CELLSSynthesis and characterization of nanoparticles is under exploration due to its wide medical applications and various research interest in nanotechnology. In the current study the plant extract of Andrographis paniculata (Family : Acanthaceae) is used for the synthesis of silver nanoparticles. The plant extract is mixed with AgNO3 and incubated and studied for its synthesis using UV–Vis spectroscopy and it was characterized by FTIR & TEM. The silver nanoparticles synthesized were generally found to be spherical in shape with 1-100 nm. The results showed that the leaf extract is optimum for the synthesis of silver nanoparticles and it is also known to have the ability to inhibit the growth of various pathogenic microorganisms. The cytotoxic ability of silver nanoparticles was tested against sheep bone marrow cells which confirms that the plant mediated synthesis of silver nanoparticles have a significant cytotoxicity against sheep’s bone marrow cell linespriyaibt@ymail.comResearch4122013Silver Nanoparticle,Cytotoxity, Bone Marrow Cell,ELISA,FTIR,TEMRavi D,Sathish S,Parthasarathy R,Priyadharshini M,Revathy MBioprocess lab, PG & Research Department of Botany, Government Arts College, Coimbatore – 641018, Tamilnadu, India.,Bioprocess lab, PG & Research Department of Botany, Government Arts College, Coimbatore – 641018, Tamilnadu, India.,Bioprocess lab, PG & Research Department of Botany, Government Arts College, Coimbatore – 641018, Tamilnadu, India.,Bioprocess lab, PG & Research Department of Botany, Government Arts College, Coimbatore – 641018, Tamilnadu, India.,Bioprocess lab, PG & Research Department of Botany, Government Arts College, Coimbatore – 641018, Tamilnadu, India.