395EFFECT OF ACID AND ALKALINE PHOSPHATASE ON SERUM TSH LEVELS AMONG HYPOTHYROID PATEINTSEnzymes are the nanomachines which powered the cells to perform the biochemical process that occur in our body. Acid and alkaline phosphatases are most recognized hydrolase enzyme which participates actively in bone metabolism such as bone reabsorption and osteogenesis respectively. Thyroid hormones also play a vital role in the similar aspects of bone growth and development. The main objective of the present study is to observe the impact of the variation in the levels of the serum acid phosphatase (ACP), alkaline phosphatase (ALP) and TSH on bone metabolism among the hypothyroid patients. The study groups consisted of 200 patients and also 150 age sex matched healthy controls. The serums TSH, acid and alkaline phosphatase concentration were measured by ELISA method .The statistical analysis was done with the help of the software MS-Excel 2007. The obtained results showed statistically significant increase in the concentration of ACP whereas concentration of ALP was in marginal values in hypothyroid patients. Based on these results, variation in the levels of these three important markers can give a view that the patients are more prone to get the bone abnormalitieseshita_basu@yahoo.comResearch512014Acid Phosphatase (ACP),Alkaline Phosphatase (ALP),Hypothyroid,Thyroid Stimulating HormoneEshita P,Dharani Priya B,Sudhakar G,Paddaiah GDepartment of Human Genetics, Andhra University, Visakhapatnam, Andhra Pradesh, India.,Coordinator, BVK PG Courses, Visakhapatnam, Andhra Pradesh, India.,Department of Human Genetics, Andhra University, Visakhapatnam, Andhra Pradesh, India.,Department of Human Genetics, Andhra University, Visakhapatnam, Andhra Pradesh, India.