397EVALUATION OF SPERMATOTOXIC ACTIVITY OF CLERODENDRUM SERRATUM IN MALE ALBINO RATSTo evaluate the potential spermatotoxic effect of Methanolic extract of Clerodendrum serratum in male albino rats. Methanolic extract of Clerodendrum serratum were given by gavage to rats in the in vivo test at a dose of 100,300 and 500mg/kg of bodyweight, along with normal controls and their by studying changes in sperm morphology consisting counts, motility and abnormalities of cauda epididymal sperm adapting light microscopy. Finding of this study revealed, the sperm concentration in the epididymis and sperm motility are decreased, whereas sperm abnormalities increased like sloughing of sperm neck, detached head, and coiling of end tail. In extract treated rats, the duration of sperm motility reduced with respect to the increased dose level. A highest 2.09-fold (p < 0.005) and 1.28-fold (p < 0.001) reduction in the sperm counts and the viability, respectively were observed in Clerodendrum serratum 500mg/kg body weight group. Sperm abnormality was increased by Clerodendrum serratum in a dose-dependent manner was assessed by acridine Orange fluorescent staining and there was a highest elevation by 2.2-fold (p < 0.001) in 500mg/kg group .This result indicates disruption of spermatogenic as well as androgenic compartment. The present study can be concluded the Clerodendrum serratum extracts suppress male fertility without altering the general metabolismnasveen@gmail.comResearch512014Clerodendrum serratum,Male contraception,Epididymis,Acridine Orange fluorescentSarathchandiran I,Kadalmani B,Navaneethakrishnan S Professor & Principal, Department of Pharmaceutics, Gokula Krishna College of Pharmacy, Sullurpet 524121,Nellore Dist., Andhra Pradesh, India, Asst Professor, Department of Animal Science, Bharathidasan University, Trichirapalli 620024, Tamil Nadu, India.,Research scholar, Department of Pharmacology, PRIST University, Vallam, Thanjavur 613403, Tamil Nadu, India.