419ANTITUMOR ACTIVITY OF ETHANOLIC AND AQUEOUS EXTRACT OF OLDENLANDIA UMBELLATA AND OLDENLANDIA CORYMBOSA AGAINST DALTON’S ASCITIC LYMPHOMA IN MICEAims of the present study to evaluate the antitumor activity of ethanolic and aqueous extract of whole plant of Oldenlandia umbellata, & Oldenlandia Corymbosa on DAL model in Swiss albino mice. Evaluation of anti tumour activity of both Oldenlandia umbellata, & Olden Corymbosa on tumour growth and hosts survival time was made by the study of the following parameters : tumour volume, viable & non-viable cell count and life span of host. The results showed decreased in tumour volume and cell viability. Haematological studies revealed that the Hb count decreased in DAL treated mice, where as it was induced by the drug treated animals and showed an increase in Hb near to normal levels. The results suggested that, the extracts of whole plant of Oldenlandia umbellata & Oldenlandia corymbosa were exhibited significant antitumor activity of DAL bearing mice. It may be concluded that the whole plant extract of EEOU, EEOC, AEOU & AEOC significantly decreasing the tumor growth, this could be the reason for the increased percentage of life span of DAL bearing mice. These could be a source of natural antitumor that could have greater importance as therapeutic agent in preventing the tumor growthmpharm76@gmail.comResearch522014Oldenlandia umbellata, Oldenlandia Corymbosa,DAL model,Antitumor activitySethuramani A,Jegadeesan M,Kavimani SLecturer, Department of Pharmacognosy, College of Pharmacy, Madurai Medical College, Madurai-625020, Tamilnadu, India,Professor & Head, Dept. Environmental & Herbal Sci., Tamil University, Thanjavur-613010, Tamilnadu, India, Professor & Head, Dept. Pharmacology, Mother Theresa Postgraduate and Research Institute of Health Sciences, Puducherry-605006, India