426EVALUATION OF IN VITRO ANTIOXIDANT ACTIVITY AND CYTOTOXICITY OF METHANOLIC EXTRACT OF Sida cordata LEAVESSida cordata is plant of malvaeceae, native to India. Present study was aimed to focus on antioxidant and cytotoxic properties of methanolic extract of Sida cordata. The antioxidant activity was evaluated by DPPH free radical scavenging method, estimating total phenolic as well as flavonoid content and cytotoxic properties was evaluated by using brine shrimp lethality bioassay. For free radical scavenging IC50 190μg/ml compared to ascorbic acid IC50 10 μg/ml. The total phenolic content was ranged from 145.45 mg/g to 130mg/gm of dry weight of extract, expressed as gallic acid equivalents. The total flavonoid concentrations was ranged from 110 to 103.33 mg quercetin/gm . The cytotoxicity was reported in terms of lethality concentration LC50 for crude extract was 263.02 μg/ml. Sida cordata can be regarded as promising candidates for natural plant sources of antioxidants as well as cytotoxic compound with significant value and can be harnessed and purified into useful therapeutic drugsrabi6686@yahoo.comResearch522014 Brine shrimp Lethality,DPPH Scavenging, Flavonoids Content,Phenolic ContentMd. Rabiul Islam,A.S.M Ali Reza,Kazi Ashfak Ahamed Chawdhury,Md. Josim Uddin,Mst. Kaniz FarhanaDepartment of Pharmacy, International Islamic University Chittagong, Bangladesh,Department of Pharmacy, International Islamic University Chittagong, Bangladesh,Department of Pharmacy, International Islamic University Chittagong, Bangladesh,Department of Pharmacy, International Islamic University Chittagong, Bangladesh,Department of Chemistry, University of Rajshahi, Bangladesh