432HEPATOPROTECTIVE ACTIVITY OF THE STEMS OF ECBOLIUM VIRIDE (FORSSK.) ALSTON. AGAINST PARACETAMOL-INDUCED HEPATOTOXICITYHepatoprotective activity of Ecbolium viride a medicinal herb commonly used in folklore system for wound healing and also against jaundice, was evaluated against Paracetamol (Acetaminophen) induced hepatic damage in male albino rats. Paracetamol (2gm/kg body weight) induced hepatic damage was well manifested by significant increase in the activities of Alanine aminotransferase, Aspartate aminotransferase, Alkaline phosphatase and total bilirubin in serum Consequent to paracetamol induced hepatic injury, the Serum level was increased. The oral administration of varying doses of different solvent extracts like ethyl acetate and methanolic extracts of Ecbolium viride (200 and 400mg/kg body weight) for the period of 10 days reversed these altered parameters to normal levels indicating the antioxidative and hepatoprotective efficacy of Ecbolium viride against paracetamol induced liver injurypreetihelia@gmail.comResearch532014Ecbolium viride,Hepatoprotective activity,Hepatotoxicity,paracetamol,SilymarinS.P.Preethi Priyadharshni,B.Ganga Rao,K.Balaram KumarA.U.College of Pharmaceutical Sciences, Andhra University,Visakhapatnam-530003, Andhra Pradesh, India,A.U.College of Pharmaceutical Sciences, Andhra University,Visakhapatnam-530003, Andhra Pradesh, India,A.U.College of Pharmaceutical Sciences, Andhra University,Visakhapatnam-530003, Andhra Pradesh, India