484ANTI-INFLAMMATORY ACTIVITY OF THE SIMPLE ASCIDIAN, PHALLUSIA ARABICA SAVIGNYThe present study investigates the acute and chronic anti-inflammatory activity in ethanolic extract of the simple ascidian Phallusia arabica. The reduction in paw volume was highly significant in Group V treated with 400 mg/kg bw followed by Group IV (200mg/kg bw), indicating a dose dependent activity compared to control. Studies on biochemical parameters of the serum, liver and exudates indicated lower lipid peroxide content and γ -glutamyl transpeptidase activity. Results showed that ethanolic extract of the Phallusia arabica had potent and significant anti-inflammatory activityapcm.research@gmail.comResearch572014Anti-inflammatory,Simple ascidian,Phallusia arabica,Ethanolic extract,IndomethacinKohila Subathra Christy H,Jothibai Margret R,Meenakshi VKDepartment of Chemistry, A.P.C. Mahalaxmi College for Women, Tuticorin, India, Department of Chemistry, Pope‟s College, Sawyerpuram, Tuticorin, India,Department of Zoology, A.P.C. Mahalaxmi College for Women, Tuticorin, India