501PREPARATION AND EVALUATION OF POLY-Ԑ-CAPROLACTONE NANOPARTICLES FOR OCULAR DELIVERYDelivery of drug to the ocular region is a challenging task. Only 1–2% of drug is available in eye for therapeutic action, remaining part of the drug is drained out through nasolachrymal drainage system and other ocular physiological barriers. To overcome such problems of conventional dosage forms, novel drug delivery systems are explored like nanoparticles. The present work aims to prepare Diclofenac sodium encapsulated ploy-ԑ-caprolactone nanoparticles by double emulsion solvent evaporation technique and evaluate for various parameters like particle size, ζ potential, invitro release and ex vivo trans corneal permeation. Developed nanoparticles were spherical in shape with mean size of 153±14.07 and ζ potential of -31.32 ±1.41. The percentage entrapment efficiency of drug loaded nanoparticles was found to be between 45-76 %. In vitro drug release studies suggest that all the formulation showed extended drug release profile. Ex vivo corneal permeability was found to be comparable with that of marketed formulation across isolated goat cornea, indicating suitability of nanoparticle formulation in ophthalmic delivery of diclofenac sodiumsatikv@gmail.comResearch582014Diclofenac Sodium,Nanoparticle,Poly-ԑ-caprolactone,Hydration test,Transcorneal permeationSatish KV,Kumar GS,Jayaveera KNDepartment of Pharmaceutics, Sri Krishna Chaithanya College of Pharmacy, Madanapalle, Andhra Pradesh, India, 517325.,Department of life sciences. School of Pharmacy, International Medical University, Jalan Jallil, 19 Perkasa, Bukit jalil 57000. Kualalumpur. Malaysia,Science Tech foundations, Sanath Nagar, Hyderabad, Telangana, India-500018.