537DENDRITIC NANOPARTICULATED CARRIERS FOR THE DELIVERY OF ANTI TUBERCULOSIS BIOACTIVESThe present study was aimed at developing and exploring the use of PPI dendrimers for delivery of anti-tuberculosis drug, Rifampicin (RMP). RMP was selected for incorporation into dendrimers based on its antitubercular activity, short biological half-life and solubility characteristics. For this study, poly (propyleneimine) dendritic architecture was loaded with Rifampicin.Various physicochemical and physiological parameters like UV, FT-IR, TEM, DSC, zeta potential, drug entrapment and drug release of formulations were determined. By constructing drug release kinetics, the release mechanism followed was a non fickian diffusion. In this, the system was found to have increased their drug-loading capacity, reduced their drug release rate. Therefore the system was found to be suitable for prolonged delivery of Rifampicinmanalanceutics@gmail.comResearch5122014PPI dendrimers,drug delivery system,Nanoparticles,Rifampicin,Prolonged releaseBalasubramanian Valli Manalan,Padmasree Kolavennu,Arulsamy Elphine Prabahar,Rama Rao Nadendla,Keerthi ManukondaDepartment of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India,Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India,Department of Pharmaceutical Analysis, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India,Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India,Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India