599FORMULATION AND EVALUATION FOR INVITRO DISSOLUTION STUDIES OF COLON TARGETED MICROSPHERES OF CAPECITABINECapecitabine microspheres are prepared as colon targeted microspheres. These were prepared by using with the sodium alginate as a polymer with different concentrations such as 4%, 5%, 6% concentrations. These prepared microspheres are filled in the EudragitS-100 coated capsules. And these microspheres were evaluated for physical characterization and in vitro dissolution studies. From the in vitro dissolution studies the 4% formulation showed good results among the other formulationst27prabhakar@gmail.comResearch642015Capecitabine,Dissolution studies,Microspheres,Formulations, Colon targetsPrabhakar Thota,Saida LavudiCenter for Biotechnology, Institute of Science and Technology, JNTUH, Kukatpalli, Hyderabad, India.,Center for Biotechnology, Institute of Science and Technology, JNTUH, Kukatpalli, Hyderabad, India.