606PULMONARY ARTERIAL HYPERTENSION INFLUENCED BY INHALATION OF PARTIALLY IONIZED OXYGEN (O2•-)Pulmonary arterial hypertension (PAH) represents a serious therapeutic problem in patients who undergo surgery for cardiovascular disease and PAH is considered as the only independent predictor of perioperative mortality, we tested possible beneficial effect of partially ionized oxygen (O2•-) inhalation on pulmonary vascular resistance (PVR) compare to medical oxygen (O2) inhalation in postoperative therapy. Twenty patients with moderate PAH (pulmonary arterial pressure PAP 34±4.5 mm Hg, Dana Point group 2) 10 case subject and 10 controls, which underwent cardio - surgery, were enrolled. Effect of inhalation of O2•- compare to O2 on postoperative PAH was observed using hemo dynamic parameters measured by pulmonary arterial catheter (PAC). Cardiac index (CI), pulmonary vascular resistance (PVR), mean pulmonary artery pressure (mPAP), systemic vascular resistance (SVR), were evaluated during specified time course before, during and after of O2•- or O2 inhalations respectively. A significant decrease in PVR was observed after O2•- inhalation in case subject (135.10 ± 23.75 dyn*s*m-5; P<0.01). In control, which inhaled only O2 decrease of PVR was not significant (197.30 ± 35.57 dyn*s*m-5; P>0.07). PAP decrease in case subject was associated with increased CI 3.04 ± 0.61 l*min-1*m-2; P=0.005) and with decreased PVR (140.90 ± 24.26 dyn*s*m-5; P<0.01) after 18-32 hour of O2•- inhalation. This improvement was present without deterioration of other hemodynamic parameters and persisted for > 3 -4 hours after disconnection from O2•-, without rebound effect. Medical oxygen O2 enriched with a Pico doses of O2•- represent important improvement of its biological properties. Inhalation of O2•- showed beneficial effect on post - operative PAH compare to inhalation of medical oxygen O2 onlyviliam.donic@upjs.skResearch652015O2 inhalation,ionized oxygen O2•-,ulmonary arterial hypertension (PAH),pulmonary vascular resistance,mean pulmonary arterial pressure, cardiac index, right ventricular failure,ionized ion therapyP. Torok,V. Donic, I. Engler,D. Rybar,S. Saladiak,V. Donicova,F. Sabol Clinic of Anaesthesiology and Intensive medicine, East-Slovakian Institute of heart and vascular diseases, Faculty of Medicine, Safarik University, Kosice, Slovak republic,Department of Human Physiology, Faculty of Medicine, Safarik University, Kosice, Slovak republic,Department of Human Physiology, Faculty of Medicine, Safarik University, Kosice, Slovak republic, Clinic of Anaesthesiology and Intensive medicine, East-Slovakian Institute of heart and vascular diseases, Faculty of Medicine, Safarik University, Kosice, Slovak republic, Clinic of Anaesthesiology and Intensive medicine, East-Slovakian Institute of heart and vascular diseases, Faculty of Medicine, Safarik University, Kosice, Slovak republic,Department of Human Physiology, Faculty of Medicine, Safarik University, Kosice, Slovak republic,Clinic of heart diseases, East-Slovakian Institute of heart and vascular diseases, Faculty of Medicine, Kosice, Slovak republic