636ROLE OF CANCER ANTIGEN-125 AND OXIDATIVE STRESS IN CLINICAL STAGES OF PRE-OPERATIVE OVARIAN CARCINOMAOvarian carcinoma is most lethal gynecologic oncologic disease with a high mortality rate. The present study was attempted to investigate role of cancer antigen-125 and oxidative stress in the clinical stages of pre-operative ovarian carcinoma. Total 160 subjects were enrolled for the study. Study group comprised of 80 clinically and histologically proved cases of ovarian carcinoma and 80 healthy women recruited as a control group. CA-125 level, MDA and catalase activity were estimated in all the subjects prior to treatment. The serum level of CA-125 and MDA were significantly higher (p=<0.001) in study group as compared to controls whereas CAT activity was significantly lower in study group as compared to control group (p=0.001). The present study concludes that CA-125 level is significantly higher in the early stages .So these findings indicate that CA-125 is a potent marker for early detection of ovarian carcinomaresearch.physiology@gmail.comResearch672015Ovarian Carcinoma,CA-125,Oxidative stress,MDA,CatalaseVerma Arti,Tiwari Sunita,Sankhwar Pusphlata,Dwivedi Anila,Tripathi Dinesh,Srivastava Rohit KumarDepartment of Physiology, King George’s Medical University, Lucknow,Department of Physiology, King George’s Medical University, Lucknow,Department of Obstetrics and Gynaecology, King George’s Medical University, Lucknow, Division of Endocrinology, Central Drug Research Institute, Lucknow,Department of Physiology, King George’s Medical University, Lucknow,Department of Physiology, King George’s Medical University, Lucknow