666PHOSPHATIDYLINOSITOL DERIVATIVE ENANTIOMERS HAVE THE DIFFERENT POTENTIAL FOR THE ANTITUMOR EFFECT AGAINST MALIGNANT PLEURAL MESOTHELIOMA CELLSWe investigated the antitumor effect of the newly synthesized phosphatidylinositol (PI) derivatives 1,2-O-bis-[8-{2-(2- pentyl-cyclopropylmethyl)-cyclopropyl}-octanoyl]-sn-glycero-3-phosphatidyl-D-1-inositol (diDCP-LA-D-PI) and its enantiomer 1,2-O-bis-[8-{2-(2-pentyl-cyclopropylmethyl)-cyclopropyl}-octanoyl]-sn-glycero-3-phosphatidyl-L-1-inositol (diDCP-LA-L-PI) on human malignant pleural mesothelioma (MPM) cells. diDCP-LA-L-PI strikingly reduced cell viability of NCI-H28, NCI-H2052, NCI-H2452, and MSTO-211H MPM cells, with the potential considerably greater than that for diDCPLA-D-PI. The results show that big difference in the potential for the antitumor effect against MPM cells is found between the enantiomers and that diDCP-LA-L-PI could be developed as an effective drug for MPM therapytomoyuki@hyo-med.ac.jpResearch692015Phosphatidyl inositol derivative,Enantiomer,Antitumor effect, Malignant pleural mesothelioma cellAyako Tsuchiya,Takeshi Kanno,Tadashi Shimizu,Akito Tanaka,Tomoyuki NishizakiDivision of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan,Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan,Laboratory of Chemical Biology, Advanced Medicinal Research Center, Hyogo University of Health Sciences, Kobe, Japan.,Laboratory of Chemical Biology, Advanced Medicinal Research Center, Hyogo University of Health Sciences, Kobe, Japan.,Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan