691HEPATOPROTECTIVE AND ANTIOXIDANT EFFECTS OF CYCAS BEDDOMEI IN RATSThe aspire of the present study was to investigate the antioxidant and hepatotective effects of Cycas beddomei methanol extract on carbon tetrachloride and olive oil (1:1) induced liver damage in wistar albino rats. In vivo antioxidant activity of methanol extract of Cycas beddomei was evaluated by varied assays together with superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GRD), reduced glutathione, glutathione peroxidase (GPx) and malondialdehyde (MDA) levels in liver tissues. Serum glutamic oxaloacetate transaminases (SGOT), Serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and total protein (TP) were estimated from serum. The serum levels of above biochemical parameters (SGOT, SGPT, ALP, LDH, bilirubin and total protein) were significantly increased; however, a significant decrease in the levels of total protein (TP) was observed in carbon tetrachloride and olive oil treated groups compared to normal control. Treatment with methanol leaf extract of Cycas beddomei and silymarin prior to carbon tetrachloride and olive oil intoxication, afforded protection by lowering of the above serum markers as well as by increasing the total protein content. The extract showed potent activities on SOD, CAT, GRD, GPx, reduced glutathione and MDA levels. The outcome indicated that Cycas beddomei methanol extract has strong antioxidant activities and significant protective consequence against hepatotoxicity induced by carbon tetrachloride and olive oil (1:1) and have been supported by the assessment of liver histopathology in ratssraja61@gmail.comResearch6112015Cycas beddomei,Serum transaminases,Carbon tetrachloride,Hepatoprotective,Histopathology.Baggiya Selvi David,Raja SundararajanDepartment of Pharmacognosy, Karnataka College of Pharmacy, Bangalore-560064, Karnataka-State, India,GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-500045, Andhra Pradesh, India