693DRUG EXCIPIENT COMPATIBILITY SCREENING OF FEXOFENADINE HYDROCHLORIDE FOR ORALLY DISINTEGRATING TABLETSSelection of right excipients of functionality is an important task to ensure the performance of dosage form across shelf life. This selection happens at pre-formulation stage of pharmaceutical development to ensure there is no potential physical and chemical interaction between drugs and excipients leading to better stability and bioavailability. The objective of this work was to study the compatibility of Fexofenadine hydrochloride with pharmaceutical excipients employed in orally disintegrating tablets by Fourier transform infrared spectroscopy (FT -IR). Different categories of excipient functionality [Diluent, disintegrant, glidant, sweetener, flavor, color and lubricant, which were indispensable part of orally disintegrating tables] were selected and physical binary mixtures were prepared with Fexofenadine hydrochloride. Compatibility was investigated by storage of drug excipient binary mixtures at isothermal stress conditions and subsequently analyzed by FT-IR. Samples were packed and exposed for accelerated stability condition [40°C/75%RH] for four weeks and analyzed by FTIR to evident solid state interaction. Based on the results all the excipients found to be compatible with Fexofenadine hydrochloride and can be further used for orally disintegrating tablet dosage formmathivanann@gmail.comResearch6112015Excipient,Interaction,Stability,Bioavailability,Incompatibility,Infra -red spectroscopy,Orally disintegrating tablets,Fexofenadine hydrochlorideMathivanan N,Chandrasekhara Rao GResearch Scholar, Faculty of Pharmaceutical Sciences, Jawaharlal Nehru technological University, Hyderabad- 500 085, Telangana, India,Department of Pharmaceutics, Yelamarty Pharmacy College, Tarluwada, Visakhapatnam – 530052, Andhra Pradesh, India