70FORMULATION AND EVALUATION OF RABEPRAZOLE SODIUM DUAL DRUG MODIFIED RELEASE CAPSULESModern drug delivery approaches have been elevated to a new concept of chronobiology. The increasing research interest surrounding this delivery system has widened the areas of pharmaceutics in particular with many more sub-disciplines expected to coexist in the near future. The present study is formulating rabeprazole sodium dual drug release capsules were developed by time release coating process varying the compositions of drug & polymer mixture in Film coating, water insoluble and enteric coating polymer mixture in lag time coating. Preparation of immediate release (IR) Rabeprazole beads has done by drug layering process and barrier coated beads by providing an enteric coating membrane on IR beads. Timed release beads has done by providing a Film coating for IR and lag time coating for TPR (Timed, Pulsatile Release) on enteric coated beads. Encapsulation Process and evaluation of enteric coated IR and TPR beads has done by physical evaluation and chemical evaluation. Stability studies have done for best quality Rabeprazole IR and TPR enteric coated beads formulations. Based on the results Formulation 3 and Formulation 9 were selected as the best formulation developed for Rabeprazole Dual Drug Release Capsules.sriharshavardhan.51@gmail.comResearch322012Rabeprazole sodium, Stability studies, Immediate Release,Pulsatile ReleaseSriharsha Vardhan S,P.V.N.SowmyaRM College of Pharmacy, Chennai, Tamil Nadu.,Vignan Institue of Pharmaceutical Science, Hyderabad, Andhra Pradesh.