720PREVENTIVE ROLE OF METHYLCOBALAMIN AGAINST THE CADMIUM INDUCED TOXICITY ON THE VITAL ORGAN OF FRESHWATER FISH, LABEO ROHITAThe persistence and ubiquitous nature of cadmium is coupled with their tendency to accumulate in organisms ultimately produce toxic reactions in aquatic biota, especially fish. Therefore, present study was carried out to evaluate th e amelioration of cadmium toxicity by methylcobalamin. The effect was investigated on the basis of histological examinations of control and experimental groups exposed to cadmium and methylcobalamin. 40 fishes of Labeo rohita, body weight ranging between 60±10 gm were used for the study and divided into four groups, with ten fishes in each group. Hepatocytes with cytoplasmic vacuolization and pyknotic nuclei, extensive vacuolization, hepatic tissue ruptured, damaged hepatocytes and hepatic portal vein clumped are found in liver of cadmium treated group while as supplementation of methylcobal amin showed recovery in their cellular structure. The recovery was more prominent in 60 days groups as compared to 30 days treated groups . Therefore, our study indicate that cadmium chloride (CdCl 2.H2 O), if present in fresh water bodies, may act as a strong toxic agent for Labeo rohita and the supplementation of methylcobalamin ameliorates its toxicitysheikhshameema@gmail.comResearch722016 Labeo rohita,Cadmium chloride,Methylcobalamin,Histology.Shamima Akhter,Mahesh TharanieS.S.L. Jain P.G. College, Vidisha, Bhopal, Madhya Pradesh, India.,S.S.L. Jain P.G. College, Vidisha, Bhopal, Madhya Pradesh, India.