735DCP-LA REVIVES UV IRRADIATION-INDUCED ELASTIC FIBER DEGRADATION AND EPITHELIAL HYPERPLASIAUltraviolet (UV) exposure causes skin damage, which includes skin thickness, formation of wrinkles, and loss of skin elasticity. UVB irradiation to the dorsal skin of HR-1 hairless mice reduced the density of elastic fibers in the extracellular matrix and thickened the epidermis. Application of the linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoicacid (DCP-LA) to the dorsal skin of mice apparently suppressed UVB irradiation-induced reduction of elastic fibers and epithelial hyperplasia, while linoleic acid and ceramide exhibited no significant beneficial effect. This indicates that DCP-LA has the potential to restore UV exposure-induced skin damage including formation of wrinkletnishizaki@bioresorganization.comResearch732016 Ultraviolet ray,Elastic fiber degradation,Epidermal thickness,DCP-LA,RestorationTomoyuki NishizakiInnovative Bioinformation Research Organization, Kobe, Japan