739NEUROTRANSMITTER PRECURSOR DRUGS ENHANCE SEASONAL ALTERATION IN MALE DOMESTIC PIGEON COLUMBA LIVIA DOMESTICAAdreno gonadal hypothalamo hypophyseal axis was tested using two neurotransmitter precursor drugs (5-HTP and LDOPA) at different time intervals in monogamous bird domestic pigeon Columba livia domestica. Male birds were divided in to three groups, each with eight individuals. Group 1 was control group. Group II was 0 hr group received 5-HTP and L-DOPA at 0 hr interval. Group III was 8 hr group and received these neurotransmitter precursor drugs at 8 hr interval. Experimentat ions were terminated after 10 days and results were obtained 45 days after later experiment. 0 hr group showed significantly inhibitory (P<0.05) responses in body weight and plasma testosterone level, while 8 hr group showed significantly stimulatory (P<0.05) effect in comparison to control. Cholesterol and ascorbic acid contents in testes and adrenal gland were found significantly high (P<0.05) in 0 hr group and significantly low (P<0.05) in 8 hr group in comparison to control. Regressive stages of adrenal gland by administration of neurotransmitter precursor drugs at 0 hr interval and prog ressive stages at 8 hr interval indicate possibility of changes in temporal synergism between adreno - gonadal axis of hypothalamusdrtajnqureshi2009@rediffmail.comResearch7320165-HTP,L-DOPA,Adrenal gland,Domestic pigeonTaj N. Qureshi,H.S. RathoreSchool of Studies in Zoology and Biotechnology, Vikram University, Ujjain-456010, India,School of Studies in Zoology and Biotechnology, Vikram University, Ujjain-456010, India