745STUDY OF NOVEL POLYHERBAL FORMULATION FOR ANTIDIABETIC ACTIVITYDiabetes mellitus is lifestyle disease rapidly spreading in India. It has been major health issue in south-east Asia and world’s largest numbers of diabetics are found in India. By 2010, 50.8 million diabetics were found and this will rise up to 87 million by 2030. Therefore looking at the scenario and possible complications of uncontrolled B.G.L, different modes of therapy have been practiced. The present work is an effort to study Antidiabetic’s activity of chick pea in streptozotocin induced diabetic rats. Chick pea is commonly known as Gram ( Cicer arietinum. Family- leguminosae). A single dose of (150 mg/kg) alloxan prepared in normal saline solution was injected intraperitoneally to induce diabetes in rats. The age matched control rats receives an equal volume of citrate buffer and used along with diabetic animals. Diabetes was confirmed after 48 hr of alloxan injection. The rats having plasma glucose level more than 300 mg/dl were selected and study was conducted for 7 days. The rats were divided into six groups and serum glucose levels were assessed by GOD - PAP method. The BGL and body weights were taken at day 1, day 3, day 5 and day 7.This investigation proves that chick pea powder shows beneficial effect in diabetes. It is found to reduce the BGL and prevented loss of Body weight in diabetic rats and does not have any effect on normal glycemic level. Thus, it can be concluded that chick pea can be used as supportive therapy for diabetes mellituspvnfolane@gmail.comResearch742016 Polyherbal Formulation,Alloxan, Antidiabetic,5% GlucosePavan N. Folane,K. R. BiyaniAnuradha College of Pharmacy, Chikhali, Dist- Buldhana - 443201, Maharashtra, India,Anuradha College of Pharmacy, Chikhali, Dist- Buldhana - 443201, Maharashtra, India