805FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF PIOGLITAZONETransdermal therapeutic systems are defined as self-contained discrete dosage forms which, when applied to the intact skin, deliver the drug(s) through the skin at controlled rate to the systemic circulation. A transdermal drug delivery device, which may be of an active or a passive design, is a device which provides an alternative route for administering medication. A drug is applied in a relatively high dosage to the inside of a patch, which is worn on the skin for an extended period of time. Through a diffusion process, the drug enters the blood stream directly through the skin. Since there is high concentration on the patch and low concentration in the blood, the drug will keep diffusing into the blood for a long period of time, maintaining the constant concentration of drug in the blood flowkokatamvanitha@gmail.com Research932018 Transdermal patches, Pioglitazone, Delivery system.Vanitha Devi K, Jayachandra Reddy P,Umasankar KVanitha Devi K, Jayachandra Reddy P,Umasankar K