817FORMULATION AND EVALUATION OF NANOSUSPENSION BY EMULSIFICATION METHODOlmesartan medoxomil (OLM), an anti-hypertensive agent administered orally has absolute bioavailability of only 26% due to the poor aqueous solubility. The present investigation aimed at enhancing the oral bioavailability of OLM by improving its solubility and dissolution rate by preparing nanosuspensions. The nanosuspensions of OLM were prepared using emulsification solvent evaporation method. Various formulation as well as process parameters were optimized in order to achieve desirable size and saturation solubility. Characterization of the prepared nanosuspension was done with respect to particle size, zeta potential, saturation solubility, dissolution rate, morphology study (SEM), in-vitro dissolution study. The results indicated that Increase in the stabilizer concentration of PVP K90 shows 98.65% of drug release, so the formulations prepared by using PVP K90 releases more drug release at the end of 30mins than the other stabilizers and follows first order kinetics. Nanosuspension seems to be a promising approach for bioavailability enhancement because of the simple method of its preparation and its universal applicability.jyoshnagolkonda@gmail.comResearch1022019Olmesartan medoxomil, PVP K90, Poloxamer 184, SEM.Jayasree G,Praveen Kumar J,Umasankar K,Jayachandra Reddy PJayasree G,Praveen Kumar J,Umasankar K,Jayachandra Reddy P