826DETERMINATION OF CHEMISTRY OF BRAIN ENZYMES IN RATS TREATED WITH GARCINIA COMBOGIAEpilepsy is the CNS disorder in which brain activity becomes abnormal causing seizures, and period of unusual behavior, loss of awareness and sensation. The world population are affected by 0.5 to 1% . The mechanism of epileptic seizures are excessive and abnormal neuronal activity in the brain of the cortex. The most common type of seizures are convulsive, generalized seizures and partial seizures. The present study was reported to identify the effect of Garcinia cambogia in rats brain of biogenic amine levels after induced seizures of MES & PTZ models. In Garcinia cambogia extract treated rats, monoamines such as NA, DA, 5-HT and GABA levels significantly restored on forebrain. Thus EEGC increases the seizure threshold and decreased the susceptibility to MES and PTZ induced seizure in rats. Hence we suggest that ethanol extract of leaves of Garcinia cambogia L. possess antiepileptic properties that may be due to restored the biogenic amines in rat brainmadhubhushan8@gmail.comResearch1032019Brain amines,Extract,Herbal,Garcinia cambogiaM. Madhubhushan,S. Seshaiah,J. Chandrudu,R. SagarDepartment of Pharmaceutical Sciences, Scient Institute of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Telangana, India,Department of Pharmaceutical Sciences, Scient Institute of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Telangana, India,Department of Pharmaceutical Sciences, Scient Institute of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Telangana, India,Department of Pharmaceutical Sciences, Scient Institute of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Telangana, India