835TO STUDY LENS WEIGHT OF MALE AND FEMALE AND ITS COMPARISION OF NUCLEAR CATARACT IN INDIANSThe term cataract is used loosely to mean the occurrence of an optical discontinuity in the lens of such magnitude as to cause a noticeable dispersion of light. Lens proteins are grouped into two classes on the basis of their solubility in water .The water soluble proteins, lens crystalline, and account for nearly 99% of total lens proteins. The water insoluble proteins are the membrane proteins, cytoskeleton proteins and aggregated crystalline. Totally 80 cases of both male and females lenses were collected and weighed in the electronic balance , whose sensitivity is ranging from10mg to 200mg.The patients age is ranging from 50-60 years were taken for the study. With aging, the proteins might also undergo non enzymatic glycation, by with carbohydrates molecules attach directly to the protein amino acid to eventually form carbonyl groups that favor protein aggregation. Most forms of cataracts manifest reduced glutathione levels might indicate loss of ability of the lenses to with stand oxidative stress.There is also direct effect of oxidative damage on cellular DNA of lens and cytoskeleton. Our study also there is no change in the weight of the lenses in both sexes in human cataractogenesis. There is no change in both the sexes because it may be due to the lens crystalline which is not attributed for much alteration of the structure of proteindrpebyreddy@yahoo.comResearch122010ataract, Alpha -crystalline polypeptide, Lens proteins, Oxidative damageSreeramulu AAssociate Professor, Department of Ophthalmology, Narayana Medical College, Nellore, Andhra Pradesh - 524003, India.